Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01307)
Xenobiotics Name
Furafylline
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
3433
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 1A1 (CYP1A1) DME Info Ki > 200 microM [1]
Cytochrome P450 1A2 (CYP1A2) DME Info IC50 = 0.3 microM [2]
References
1 A ligand-based drug design. discovery of 4-trifluoromethyl-7,8-pyranocoumarin as a selective inhibitor of human cytochrome P450 1A2. J Med Chem. 2015 Aug 27;58(16):6481-93.
2 Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM). Eur J Med Chem. 2015 Oct 20;103:210-22.

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