Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01478)
Xenobiotics Name
Sulforafan
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 3 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
5350
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [3]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [4]
NADPH-dependent carbonyl reductase 3 (CBR3) DME Info Homo sapiens [5]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [6], [7]
Cytochrome P450 4F2 (CYP4F2) DME Info Homo sapiens [8]
Dihydrothymine dehydrogenase (DPYD) DME Info Homo sapiens [9]
Glutathione reductase (GSR) DME Info Homo sapiens [10]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [11]
Glutathione S-transferase mu-1 (GSTM1) DME Info Homo sapiens [12]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [13]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [14]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [15]
References
1 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
2 Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells. Amino Acids. 2012 Feb;42(2-3):641-53.
3 Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells. Clin Cancer Res. 2009 Mar 15;15(6):1964-72.
4 Acetylcholinesterase is involved in apoptosis in the precursors of human muscle regeneration. Chem Biol Interact. 2010 Sep 6;187(1-3):96-100.
5 Receptor-dependent regulation of the CYP3A4 gene. Toxicology. 2002 Dec 27;181-182:199-202.
6 Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin. Thromb Haemost. 2008 Jul;100(1):119-26.
7 Taurocholate induces cyclooxygenase-2 expression via the sphingosine 1-phosphate receptor 2 in a human cholangiocarcinoma cell line. J Biol Chem. 2015 Dec 25;290(52):30988-1002.
8 Inhibition of apoptotic signalling in spermine-treated vascular smooth muscle cells by a novel glutathione precursor. Cell Biol Int. 2010 Apr 1;34(5):503-11.
9 ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism. Endocr Res. 2004 Nov;30(4):787-94.
10 Comparative mechanisms of PAH toxicity by benzo[a]pyrene and dibenzo[def,p]chrysene in primary human bronchial epithelial cells cultured at air-liquid interface. Toxicol Appl Pharmacol. 2019 Sep 15;379:114644.
11 Soyasaponins inhibit the proliferation of Hela cells by inducing apoptosis. Exp Toxicol Pathol. 2007 Sep;59(1):35-42.
12 Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity. Cancer Lett. 2006 Dec 8;244(2):239-46.
13 Profiling of bisphenol S towards nuclear receptors activities in human reporter cell lines. Toxicol Lett. 2017 Nov 5;281:10-19.
14 In vitro assessment of P450 induction potential of novel chemopreventive agents SR13668, 9-cis-UAB30, and pentamethychromanol in primary cultures of human hepatocytes. Chem Biol Interact. 2009 May 15;179(2-3):263-72.
15 Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 2015 Dec 5;242:107-22.

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