General Information of DME (ID: DME1002)
DME Name Dipeptidase (pepV), Lactococcus lactis
Synonyms Dipeptidase pepV; Glycosyl-phosphatidylinositol-anchored renal dipeptidase; F4V48_10275; RU90_GL001300; pepV
Gene Name pepV
UniProt ID
Q84BU9_LACLH
EC Number    EC: 3.4.13.-     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Dipeptidase
EC: 3.4.13.-
Lineage    Species: Lactococcus lactis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Lactococcus
Species: Lactococcus lactis
Subspecies: Lactococcus lactis subsp. hordniae (hT)
Subspecies: Lactococcus lactis subsp. cremoris (L6)
Subspecies: Lactococcus lactis subsp. lactis (L9)
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTTIDFKAEVEKLKDALMEDLFSLLRIDSAMDMEHADAENPFGPGPRKALDAFLKIAERD
GYTTKNYDNYVGHFEYENGASDDAEVLGIIGHLDVVPAGSGWDSNPFEPEIRNGNLYARG
ASDDKGPTVACYYALKILKELNLPLSKKIRFIVGTNEETGWADMDYYFEHCELPLPDFGF
SPDAEFPIINGEKGNITEYLHFAGKNAGEVVLHSFKAGLAENMVPESATAVISGAKDLQA
ALEKFVAEHASKNLRFDLEETAGKATVTLYGKSAHGAMPEKGVNGATYLTLFLNQFNFAD
GAAAFIKVGAEKLLEDHEGEKLGTAYVDELMGNTSMNAGVWSFDENSEGKIALNFRFPQG
NSPERMQEILAKLDGVVEVELSKHLHVPHYVPMSDPLVSTLIDVYEKHTGLKGYETIIGG
GTFGRLLERGVAYGAMFEGEPDSMHQANEMKPVENIYKAAVIYAEAIYELTK
Function This enzyme catalyzes the conversion of dipeptides into amino acids.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          3 Drugs
Enalapril
Drug Info Approved Essential hypertension ICD11: BA00 [1]
Spirapril
Drug Info Approved Essential hypertension ICD11: BA00 [1]
Enalaprilat
Drug Info Approved Essential hypertension ICD11: BA00 [1]
References
1 Characterization and kinetic analysis of enzyme-substrate recognition by three recombinant lactococcal PepVs. Arch Biochem Biophys. 2006 Oct 15;454(2):137-45.

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