Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1023)
DME Name Beta-lactamase (blaB), Klebsiella pneumoniae
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; bla_2; NCTC5046_06338
Gene Name bla_2
UniProt ID
A0A378EHS6_KLEPR
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Klebsiella pneumoniae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella pneumoniae
Subspecies: Klebsiella pneumoniae subsp. Rhinoscleromatis
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human lung.
Sequence
MVMRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRA
DERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGEL
CAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPRRRPATPL
PRPAWPRPCASC
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          5 Drugs
Levofloxacin
 Drug Info Approved Bronchitis ICD11: CA20 [1]
Cefotaxime
 Drug Info Approved Meningitis ICD11: 1A62 [1]
Aztreonam
 Drug Info Approved Cystic fibrosis ICD11: CA25 [1]
Cefoxitin
 Drug Info Approved Peritonitis ICD11: DC50 [1]
Cefazolin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Cotrimoxazole
 Drug Info Phase 4 Human immunodeficiency virus infection ICD11: 1C60 [1]
References
1 Analysis of the drug-resistant characteristics of Klebsiella pneumoniae isolated from the respiratory tract and CTX-M ESBL genes. Genet Mol Res. 2015 Oct 5;14(4):12043-8.

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