Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1023)
DME Name	Beta-lactamase (blaB), Klebsiella pneumoniae	DME Info
UniProt ID	A0A378EHS6_KLEPR
EC Number	EC: 3.5.2.6 (Click to Show/Hide the Complete EC Tree) Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Klebsiella pneumoniae (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Klebsiella Species: Klebsiella pneumoniae Subspecies: Klebsiella pneumoniae subsp. Rhinoscleromatis
Interactome

Interactions between Xenobiotics and DME (XEOTIC)
Amino Acid(s), Peptide(s) or Protein(s)
Peptide		Click to Show/Hide the Full List of Xenobiotics: 162 Xenobiotics
Anopheles cecropin-A amidated isoform		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02230 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Anopheles cecropin-A amidated isoform inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 1-2.5 microM)				[1], [2]
Antimicrobial peptide eNAP-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02280 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Antimicrobial peptide eNAP-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[3]
Arachnid gomesin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03497 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Arachnid gomesin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 3.15-6.25 microM)				[4]
Ascaphin-5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02325 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ascaphin-5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 13 microM)				[5]
Bactenecin 5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02370 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bactenecin 5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[6]
Bactenecin 7		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02371 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bactenecin 7 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 12 ug/ml)				[7]
Bacteriocin delta-lysin I		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03137 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bacteriocin delta-lysin I inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[8]
Bacteriocin L-1077		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02378 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bacteriocin L-1077 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 0.76 ug/ml)				[9]
Bass hepcidin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02416 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bass hepcidin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[10], [11]
Big defensin crabs		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02451 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Big defensin crabs inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[12], [13]
Bradykinin-potentiating BmK3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02491 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Bradykinin-potentiating BmK3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 2.8 microM)				[14], [15]
Brevinin-1AUa		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02496 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-1AUa inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 50 microM)				[16]
Brevinin-1AUb		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02497 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-1AUb inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC > 50 microM)				[16]
Brevinin-1CG5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02512 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-1CG5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 150 microM)				[17]
Brevinin-1TSa		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02566 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-1TSa inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC > 100 microM)				[18]
Brevinin-2TSa		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02637 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Brevinin-2TSa inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 6 microM)				[18]
Caerin-1.11		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02688 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Caerin-1.11 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 25 microM)				[19], [20]
Caerulein precursor fragment-SP1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02942 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Caerulein precursor fragment-SP1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[21]
Canine beta-defensin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02708 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Canine beta-defensin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 20 ug/ml)				[22]
Canine beta-defensin cBD-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02749 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Canine beta-defensin cBD-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 20 mug/ml)				[22]
Cathelicidin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02732 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cathelicidin-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 1.25 microM)				[23]
Cathelicidin-BF		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02743 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cathelicidin-BF inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 4.7 ug/ml)				[24], [25]
Cecropin-B(1-7)-melittin(4-11) hybrid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02767 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cecropin-B(1-7)-melittin(4-11) hybrid inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[26]
CP-P derivative K11		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03678 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	CP-P derivative K11 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 2 ug/ml)				[27]
CTX-1 peptide NCP-3a		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04241 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	CTX-1 peptide NCP-3a inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[28]
CTX-1 peptide NCP-3b		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04242 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	CTX-1 peptide NCP-3b inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[28]
Cyclic cationic V1 peptide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03029 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cyclic cationic V1 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 0.145 microM)				[29]
Cyclic cationic V2 peptide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03030 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cyclic cationic V2 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 0.643 microM)				[29]
Cyclic cationic V3 peptide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03031 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cyclic cationic V3 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 0.01 microM)				[29]
Cyclic cationic V4 peptide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03032 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cyclic cationic V4 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC < 0.005 microM)				[29]
Cyclic cationic V5 peptide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03033 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cyclic cationic V5 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC > 0.692 microM)				[29]
Cyclic cationic V6 peptide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03034 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cyclic cationic V6 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 0.004 microM)				[29]
Cyclic cationic V7 peptide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03035 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Cyclic cationic V7 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 0.458 microM)				[29]
Decoralin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03089 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Decoralin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 80 microM)				[30]
Defensin Cll-dlp		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03112 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Defensin Cll-dlp inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC > 50 ug/ml)				[31]
Defensin sapecin-B		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04905 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Defensin sapecin-B inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[32], [33]
Dermaseptin-like PBN2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03162 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Dermaseptin-like PBN2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 0.8 microM)				[19]
Drosophila cecropin-A1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03224 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Drosophila cecropin-A1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 1-2.5 microM)				[34], [35]
Dybowskin-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03235 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Dybowskin-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 60 ug/ml)				[36]
Dybowskin-3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03237 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Dybowskin-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC > 100 ug/ml)				[36]
Dybowskin-4		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03238 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Dybowskin-4 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 15 ug/ml)				[36]
Dybowskin-5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03239 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Dybowskin-5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 50 ug/ml)				[36]
Enterocin 96		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03250 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Enterocin 96 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[37]
Enterocin AS-48		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03251 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Enterocin AS-48 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[38]
Enterocin E-760		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03253 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Enterocin E-760 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 3.2 ug/ml)				[39]
Fowlicidin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02734 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Fowlicidin-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 0.40 microM)				[40]
Fowlicidin-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02736 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Fowlicidin-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 0.66 microM)				[41]
Fowlicidin-3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02738 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Fowlicidin-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 1 microM)				[42]
Gaegurin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03436 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Gaegurin-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 100 ug/ml)				[43]
Gaegurin-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03437 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Gaegurin-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 25 ug/ml)				[43]
Gaegurin-3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03438 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Gaegurin-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 25 ug/ml)				[43]
Gaegurin-4		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03439 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Gaegurin-4 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 25 ug/ml)				[44]
Gaegurin-5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03440 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Gaegurin-5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 50 ug/ml)				[43]
Gaegurin-6		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03441 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Gaegurin-6 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 50 ug/ml)				[43]
GGN4 analogue peptide D16W		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03052 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	GGN4 analogue peptide D16W inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 10 ug/ml)				[45]
Gly-rich Pg-AMP		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04548 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Gly-rich Pg-AMP inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 32000 ug/ml)				[46]
Hadrurin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03519 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Hadrurin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[47]
Hagfish HFIAP-1/2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03556 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Hagfish HFIAP-1/2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 8-16 ug/ml)				[48]
Hagfish HFIAP-3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03557 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Hagfish HFIAP-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 8-16 ug/ml)				[48]
Halocyntin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03522 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Halocyntin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[49]
Heligoland antimicrobial peptide A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04762 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Heligoland antimicrobial peptide A inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC > 25 microM)				[50]
Hematopoietic antimicrobial MgCath37		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03540 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Hematopoietic antimicrobial MgCath37 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 8-16 ug/ml)				[48]
Heteroscorpine-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03549 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Heteroscorpine-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[51]
Human beta-defensin hBD-28		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03591 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Human beta-defensin hBD-28 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 50 ug/ml)				[52]
Human beta-defensin hBD-3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03593 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Human beta-defensin hBD-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 25 ug/ml)				[52], [53]
Hydramacin Hm-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03609 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Hydramacin Hm-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[54], [55]
Immobilized peptide E07LKK		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03633 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Immobilized peptide E07LKK inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[56]
Immobilized peptide E10KKL		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03630 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Immobilized peptide E10KKL inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[56]
Immobilized peptide E12LLK		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03631 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Immobilized peptide E12LLK inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[56]
Immobilized peptide E14KKL		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03632 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Immobilized peptide E14KKL inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[56]
Immobilized peptide E14LKK/H14LKK		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03634 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Immobilized peptide E14LKK/H14LKK inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[56]
Immobilized peptide E16LKL		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03635 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Immobilized peptide E16LKL inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[56]
Immobilized peptide E17HSA magainin 2 deletion		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03636 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Immobilized peptide E17HSA magainin 2 deletion inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[56]
Immobilized peptide E17KGG		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03637 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Immobilized peptide E17KGG inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[56]
Immobilized peptide E18KGG		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03638 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Immobilized peptide E18KGG inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[56]
Immobilized peptide E23GIG magainin 2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03639 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Immobilized peptide E23GIG magainin 2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[56]
Immobilized peptige E16KGL/H16KGL		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03640 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Immobilized peptige E16KGL/H16KGL inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[56]
Insect cecropin-A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02768 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Insect cecropin-A inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 1-2.5 ug/ml)				[57]
Jellein-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03672 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Jellein-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 10 ug/ml)				[58]
Jellein-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03673 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Jellein-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 15 ug/ml)				[58]
Jellein-3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03674 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Jellein-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[58]
Jindongenin-1a		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03675 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Jindongenin-1a inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 15 microM)				[59]
Kassinatuerin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03697 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Kassinatuerin-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 25 microM)				[60], [61]
L10 peptide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03724 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	L10 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 3.35 microM)				[62]
L5K5Wn model peptide L5K5W1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03746 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	L5K5Wn model peptide L5K5W1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 2 ug/ml)				[63]
L5K5Wn model peptide L5K5W10		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03747 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	L5K5Wn model peptide L5K5W10 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 2 ug/ml)				[63]
L5K5Wn model peptide L5K5W11		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03748 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	L5K5Wn model peptide L5K5W11 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 4 ug/ml)				[63]
L5K5Wn model peptide L5K5W2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03749 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	L5K5Wn model peptide L5K5W2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 2 ug/ml)				[63]
L5K5Wn model peptide L5K5W3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03750 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	L5K5Wn model peptide L5K5W3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 2 ug/ml)				[63]
L5K5Wn model peptide L5K5W4		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03751 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	L5K5Wn model peptide L5K5W4 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 4 ug/ml)				[63]
L5K5Wn model peptide L5K5W5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03752 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	L5K5Wn model peptide L5K5W5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 2 ug/ml)				[63]
L5K5Wn model peptide L5K5W7		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03754 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	L5K5Wn model peptide L5K5W7 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 2 ug/ml)				[63]
L5K5Wn model peptide L5K5W8		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03755 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	L5K5Wn model peptide L5K5W8 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 4 ug/ml)				[63]
L5K5Wn model peptide L5K5W9		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03756 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	L5K5Wn model peptide L5K5W9 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 2 ug/ml)				[63]
LlKmWn model peptide L5K3W5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03744 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	LlKmWn model peptide L5K3W5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 6.3 ug/ml)				[64]
LlKmWn model peptide L5K5W6		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03753 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	LlKmWn model peptide L5K5W6 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 6.3 ug/ml)				[64]
LlKmWn model peptide L6K4W6		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03759 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	LlKmWn model peptide L6K4W6 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 3.1 ug/ml)				[64]
LlKmWn model peptide L7K3W6		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03761 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	LlKmWn model peptide L7K3W6 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 50 ug/ml)				[64]
Magainin-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03985 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Magainin-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 10 ug/ml)				[65], [66]
Mastoparan MP-L		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04001 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mastoparan MP-L inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 12.5 microM)				[67]
Mastoparan-L [I5,R8] derivative		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01816 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mastoparan-L [I5,R8] derivative inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 6.25 microM)				[67]
Maximin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04007 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Maximin-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 9 ug/ml)				[68], [69]
Maximin-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04011 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Maximin-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 9 ug/ml)				[68], [69]
Maximin-3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04012 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Maximin-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 3.1 ug/ml)				[68], [69]
Maximin-4		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04013 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Maximin-4 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 15 ug/ml)				[68], [69]
Maximin-5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04014 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Maximin-5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 3.6 ug/ml)				[68], [69]
Microcin 7		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04111 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Microcin 7 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[70]
Mollusca/molluscs/mollusks peptide 2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04531 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mollusca/molluscs/mollusks peptide 2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[71]
Mollusca/molluscs/mollusks peptide 3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04533 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mollusca/molluscs/mollusks peptide 3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[71]
Mollusca/molluscs/mollusks peptide 4		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04534 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mollusca/molluscs/mollusks peptide 4 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[71]
Mollusca/molluscs/mollusks peptide 5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04535 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mollusca/molluscs/mollusks peptide 5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[71]
Mollusca/molluscs/mollusks peptide 6		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04536 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mollusca/molluscs/mollusks peptide 6 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[71]
Mollusca/molluscs/mollusks peptide 7		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04537 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mollusca/molluscs/mollusks peptide 7 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[71]
Mollusca/molluscs/mollusks peptide 8		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04538 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mollusca/molluscs/mollusks peptide 8 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[71]
Mollusca/molluscs/mollusks peptide 9		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04539 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Mollusca/molluscs/mollusks peptide 9 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[71]
Nematode ABF-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02115 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Nematode ABF-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[72]
Ocellatin-F1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04348 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ocellatin-F1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 80 microM)				[73]
Ocellatin-P1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04349 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ocellatin-P1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 100 microM)				[74]
Opistoporin-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04399 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Opistoporin-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 6.3 microM)				[75]
Papillosin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04468 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Papillosin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[49]
Parabutoporin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04471 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Parabutoporin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 1.6 microM)				[76]
Penaeidin-2d		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04506 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Penaeidin-2d inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC > 20 microM)				[77], [78]
Penaeidin-3a		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04507 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Penaeidin-3a inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC > 40 microM)				[79]
Penaeidin-3a T8A		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01827 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Penaeidin-3a T8A inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC > 50 microM)				[79]
Penaeidin-4a		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04510 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Penaeidin-4a inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC > 50 microM)				[77], [80]
Phylloseptin PS-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04571 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Phylloseptin PS-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[81]
Phylloseptin PS-3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04572 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Phylloseptin PS-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[82], [83]
Pilosulin Myr b I		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04606 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Pilosulin Myr b I inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 2 microM)				[84]
Pilosulin P1(1-20)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04426 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Pilosulin P1(1-20) inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 2 microM)				[85]
Piscidin Pis-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04612 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Piscidin Pis-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 2.5-5 microM)				[86]
Piscidin Pis-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04613 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Piscidin Pis-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 2.5-5 microM)				[87]
Ponericin G1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04695 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin G1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[88]
Ponericin G3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04696 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin G3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[88]
Ponericin G4		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04697 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin G4 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[88]
Ponericin G6		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04698 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin G6 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[88]
Ponericin-L2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04699 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin-L2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[88]
Ponericin-W1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04700 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin-W1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[88]
Ponericin-W3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04701 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin-W3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[88]
Ponericin-W4		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04702 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin-W4 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[88]
Ponericin-W5		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04703 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ponericin-W5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[88]
PYLa/PGLa A chain PGLa		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04549 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	PYLa/PGLa A chain PGLa inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 250-500 ug/ml)				[89], [90]
Ranatuerin-2AUa		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04809 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Ranatuerin-2AUa inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 10 microM)				[16]
SAAP fraction 3		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04891 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	SAAP fraction 3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[91]
Sapecin-C		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04906 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Sapecin-C inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[32]
Scorpine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04917 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Scorpine inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 10 microM)				[92]
Single AA substitution D16F-N23		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03051 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Single AA substitution D16F-N23 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 100 ug/ml)				[45]
Single AA substitution D16W-N23		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03053 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Single AA substitution D16W-N23 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 25 ug/ml)				[45]
Spheniscin-2		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04971 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Spheniscin-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 50-100 microM)				[93], [94]
Spider gomesin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03498 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Spider gomesin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 3.15-6.25 microM)				[4]
Spinigerin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04974 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Spinigerin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 50-100 microM)				[95], [96]
Stomoxyn		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04995 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Stomoxyn inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 0.78-1.56 microM)				[96], [97]
Tachycitin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05020 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Tachycitin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[98], [99]
Temporin-1Va		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05073 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-1Va inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 80 microM)				[100]
Temporin-1Vc		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05075 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-1Vc inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 80 microM)				[100]
Temporin-Ra		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05101 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-Ra inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 31.2 ug/ml)				[101]
Temporin-Rb		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05102 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Temporin-Rb inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 35.1 ug/ml)				[101]
Thanatin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05120 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Thanatin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 0.6-1.2 microM)				[102], [103]
Thanatin truncated isoform I14M(8-21)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03622 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Thanatin truncated isoform I14M(8-21) inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 20-40 microM)				[102]
Thanatin truncated isoform K18M(4-21)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03681 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Thanatin truncated isoform K18M(4-21) inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 1.2-2.5 microM)				[102]
Thanatin truncated isoform V16M(6-21)		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05220 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Thanatin truncated isoform V16M(6-21) inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 2.5-5 microM)				[102]
Toad bombinin-like peptide BLP-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02473 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Toad bombinin-like peptide BLP-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[104], [105]
Tracheal antimicrobial peptide		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05163 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Tracheal antimicrobial peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae (MIC = 12-25 ug/ml)				[106], [107]
Natural Product(s), Extract(s) or Medicine(s)
Plant Extract		Click to Show/Hide the Full List of Xenobiotics: 5 Xenobiotics
Himatanthus drasticus butanolic extract		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02656 XEOTIC Info		Gene Form	Protein
Classification	Plant Extract
DME Modulation	Himatanthus drasticus butanolic extract inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[108]
Himatanthus drasticus hydroalcoholic extract		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03611 XEOTIC Info		Gene Form	Protein
Classification	Plant Extract
DME Modulation	Himatanthus drasticus hydroalcoholic extract inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[108]
Hyptis suaveolens hexane extract		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03552 XEOTIC Info		Gene Form	Protein
Classification	Plant Extract
DME Modulation	Hyptis suaveolens hexane extract inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[109]
Thymus vulgaris ethanol extract		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03348 XEOTIC Info		Gene Form	Protein
Classification	Plant Extract
DME Modulation	Thymus vulgaris ethanol extract inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[110]
Thymus vulgaris methanol extract		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04087 XEOTIC Info		Gene Form	Protein
Classification	Plant Extract
DME Modulation	Thymus vulgaris methanol extract inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[110]
Pharmaceutical Agent(s)
Approved/Marketed Drug		Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
Cefixime		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02780 XEOTIC Info		Gene Form	Protein
Classification	Drug Approved by US FDA
DME Modulation	Cefixime inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[111]
Drug in Phase 2 Clinical Trial		Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
Salicylic acid		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00546 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 2/3
DME Modulation	Salicylic acid inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[112]
Drug in Phase 1 Clinical Trial		Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
Cyanidin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO01266 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	Cyanidin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[113]
Phenanthrene		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00574 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 1
DME Modulation	Phenanthrene inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[109]
Investigative Agent		Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
Norspermidine		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO04331 XEOTIC Info		Gene Form	Protein
Classification	Investigative Agent
DME Modulation	Norspermidine inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[114]
Other Chemical Compound(s) or Element(s)
Chemical Compound		Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
Ferric chloride		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO03387 XEOTIC Info		Gene Form	Protein
Classification	Chemical Compound
DME Modulation	Ferric chloride inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Klebsiella pneumoniae				[115]

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