Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1033)
DME Name Beta-lactamase (blaB), Edwardsiella tarda
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; blaC
Gene Name blaC
UniProt ID
A4LA84_EDWTA
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Edwardsiella tarda     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Hafniaceae
Genus: Edwardsiella
Species: Edwardsiella tarda
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MMNTRLSCTLALSALLLSSGAQASTPPSAEMRVAEAVKQTIPALMQQQQIPGMAVAVIYQ
GTPYYFSYGVADKATRRAVTPQTLFELGSVSKTFTGVLGGYALQRGDIRLQDTVASQWPA
LNGPQWRAITLQQLATYTAGGLPLQVPDAVTDTAQLLDFYQRWQPRWAPGTMRSYSNASI
GLFGMLAVRPSGMDFSQAMTRWVLQPLGLKHTYFRVPPAAEGEYAWGYREGKALRVSPGM
LEQEAYGIKSSAQDMATWLQANLDPAAVTQATLRQALLRAQTRYYQSGEMYQGLGWEMLS
WPLQAQTLIDGSDNRVALQPQPVHLIEPPTPPQPASWVHKTGSTNGFGAYIAFIPGSRLG
IVMLANKNYPNPARVQAAYTILQQLQ
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Clindamycin
 Drug Info Approved Acne vulgaris ICD11: ED80 [1]
References
1 Comparison of antimicrobial susceptibility, beta-lactamase production, plasmid analysis and serum bactericidal activity in Edwardsiella tarda, E. ictaluri and E. hoshinae. J Med Microbiol. 1993 Oct;39(4):273-81.

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