Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1047)
DME Name Beta-glucosidase (bglA), Trichophyton rubrum
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; TERG_00481
Gene Name bglA
UniProt ID
F2SBM1_TRIRC
Gene ID
10373795
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Trichophyton rubrum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Fungi
Phylum: Ascomycota
Class: Eurotiomycetes
Order: Onygenales
Family: Arthrodermataceae
Genus: Trichophyton
Species: Trichophyton rubrum
Subspecies: Trichophyton rubrum NCPF 0118
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human skin.
Sequence
MLFRWCPLVALAIASGTAATESWESPPYYPSPWTKGEGEWEAAYQKAVSFVSQLTLAEKV
NLTTGVGWMQESCVGQVGSIPRLGFRSLCMQDGPLGIRFGDYVTAFPAGINVAATWSREL
AYLRGKAMGEEFRGKGADVILGPAIGPIGRAPEGGRNWEGLGPDPVLAGKLVAETIKGMQ
KSGVIACAKHFIANEQERFRIAAEAQGYGFDIAESISSNVDDVTMHEIYLWPFADAVKAG
VGSIMCSYNQINNSYGCGNSYTQNKLLKGELGFRGFIMSDWQAHHSGVGSAFAGLDMSMP
GDTLFGTGVSYWGANLTIAVANGTIPEWRVDDMAVRIMAAYYKVGRDQVQVPINFNSWTT
DVEGYQHALVKEGYGVVNQRVNVRDHHAQIARRVARDSTVLLKNEGVLPLTGTEQFTAII
GEDAGPNINGPNSCPDRGCDNGTLAMGWGSGTTNFPYLVTPDDAIQREIVGKGVGNVMSV
LQNGDFKNIQSVAGQADVALVFINSDSGEGYISVDGNEGDRKNLTTWKGGDEMVKQVTSV
CNNTVLVIHSSGPILAGEWHDNPNITAILWAGLPGQESGNALVDILYGKENPGGKSPFTW
ARTAEDYGTTILREPNNGKGAPQHLFSEGIMFEYRHFDQKNITPVYEFGYGLSYTTFSYS
NLKVRPMRANKYVPATGMTKPAPRLGHSSTKYADYLFPGGFKGVTKYVYSWLTSTDPKEA
SGDKNYGMPLEDYVPPNANNGDAQPVLPASGVPGGNPGLFEDLYEVSAVITNDGDRVGEE
VPQLYISLGGDRNAKVVLRGFDRIRLAPHQRFRWRTTITRRDVSNWDPASQDWVMTENPK
IVYVGSSSRNLPLQAPLPAPNLA
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Esculin
 Drug Info Investigative Appendicitis ICD11: DB10 [1], [2]
References
1 A prodrug approach to the use of coumarins as potential therapeutics for superficial mycoses. PLoS One. 2013 Nov 18;8(11):e80760.
2 Isolation of transcripts overexpressed in the human pathogen Trichophyton rubrum grown in lipid as carbon source. Can J Microbiol. 2011 Apr;57(4):333-8.

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