Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1353)
DME Name Gamma-glutamylcyclotransferase (GGCT), Ralstonia solanacearum
Synonyms Gamma-glutamyl cyclotransferase; Glutamylcyclo-transferase gamma; Cytochrome c-releasing factor 21; AR466_12245
Gene Name GGCT
UniProt ID
A0A073ACX1_RALSL
EC Number    EC: 4.3.2.9     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-nitrogen lyase
Amidine-lyase
EC: 4.3.2.9
Lineage    Species: Ralstonia solanacearum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Burkholderiaceae
Genus: Ralstonia
Species: Ralstonia solanacearum
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human vagina.
Sequence
MAVTREDLEQNRLRAALGDSPVASTLLTEAALEASLTSTLARLSAPPCDGQDAWVFGYGS
LIWNPMIFHTEATCATVHGYHRGFYLYSRINRGTWDNPGLVLGLDRGGSCHGVAFRVPRA
HAEREFRVLWRREMMTGAYLPRWLPTEIHGERILALAFVMNRTHEAYAGRLPDERVLGCL
HKAVGLYGPAREYLQRTLIGLASNGLHDPYLDRLWQRLQAMDAANAPSQAEDATGTGPSP
DPYLSA
Pathway Glutathione metabolism (rsy00480 )
Metabolic pathways (rsy01100 )
Function This enzyme acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine and acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
ANW-43980
 Drug Info Phase 2 Parkinsonism ICD11: 8A00 [1], [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR007250 Gammma-glutamyl amino acids 5-oxoproline Unclear - Unclear ANW-43980 [3]
References
1 Characterization of the mechanism of thioredoxin-dependent activation of gamma-glutamylcyclotransferase, RipAY, from Ralstonia solanacearum. Biochem Biophys Res Commun. 2020 Mar 12;523(3):759-765.
2 Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case-control study. BJOG. 2019 Feb;126(3):349-358.
3 Sexual dimorphism in glutathione metabolism and glutathione-dependent responses

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