Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2014)
DME Name Insulin-degrading enzyme (ide), Vibrio vulnificus
Synonyms Insulin-degrading protein; Bacterial insulin protease; Bacterial insulinase; Bacterial insulysin
Gene Name ide
UniProt ID
A0A0C1JXV9_9BACT
EC Number    EC: 3.4.24.56     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Metallopeptidase
EC: 3.4.24.56
Lineage    Species: Vibrio vulnificus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: Vibrio vulnificus
Interactome
(loading-time for this interactome depdends on the speed of web connection)
       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSDPLYSIFFKPSTIKAMKINYLIITLGCIGSLLGFPLLPALENKGYTLIEDKALLKVKT
PTFSQTQVLKIKLNNGLQAVLISDPQTDQSSATLVVGAGSWQDPDPYPGLAHFVEHMLFL
GTKKYPNESEFQRFITEHGGFSNAFTANDHTAYMFSIDNEAFPQALDRFASFFKEPLFNV
SGIVRELNAIDQEYAKNYENDDVREVMVMKHIQNPRHPNYRFNIGNSTTLKAASQEILKA
WYNEHYSSNIMRLLLVSNLPLEEMTRLTVDEFGDVADKHKVCYVPPMDLNNPDMEAKLFY
ITPIQNIRKLTLVWDLPQEFAEMKDTYPDRLICQVLGHEGKESLLAQLKREKLAENLGCS
TFNLGEKNLVLFVQMELTDKGVQSIDRIILRCFQTLALMKEKPFPRYIYDEVRQINLLNY
EYQQREEVFTAAMKNADLLVRENIATYPEQTKVIQKFSQADVQNLLDYLTPSNCRFLIQA
PSSLTGVEPTHQEEWLQVAYAMKAIEPFKMQEWASATPIAEITLPLPNPFLPKSLDLLHA
LPSKETHLSRLPHPHLIEDSEHGTIYYAKDQHFLIPQLYLNFNIRTPAIDIGDANKIVMG
DIYIKAVEENLSKFSYAATVAGLNFSVARTEYGLAFKITGYNDHAFLLFEEILKQLKDLK
LSEQAFKIIKQSLLRRYQNFNKRAPLKRAKELFQQTIYKKYAAEHQKISAIRKLSFAKFQ
EDVQSLFRQSFVEGLIYGNVTENQAKEYADNLIKTLDSAPYPKQMHKHAEIINLSSAEGP
LLLEMKIPVQGSATLLAIENSSFTLKERAAQQILMKAMKEPFFAELRTRQQTGYLISSAA
EEIERKLFLAFVVQSNTHDPRDLLARFELFIESFLQGIEKNYLTLKNFEIIKNSLLEELE
KPPHNMESLGALLHSLAFKYEGRFDWIDKRIQALRALTHGELLSFTHACIGKDNKRRLGL
LIKGHMDKAKGLYYTLINTPEQLKQKSTFSSSWGNEEKERKLE
Function This enzyme catalyzes the hydrolysis of insulin.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Insulin
 Drug Info Investigative Diabetes mellitus ICD11: 5A10 [1], [2]
References
1 Vibrio vulnificus secretes an insulin-degrading enzyme that promotes bacterial proliferation in vivo. J Biol Chem. 2015 Jul 24;290(30):18708-20.
2 Complete genome sequence of Vibrio vulnificus FORC_017 isolated from a patient with a hemorrhagic rash after consuming raw dotted gizzard shad. Gut Pathog. 2016 Jun 20;8:22.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.