Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1068)
DME Name Aminoglycoside O-phosphotransferase (aphA6), Acinetobacter baumannii
Synonyms Aminoglycoside 3'-phosphotransferase; Kanamycin kinase, type VI; Neomycin-kanamycin phosphotransferase type VI; APH(3')VI; aphA-6
Gene Name aphA-6
UniProt ID
KKA6_ACIBA
Gene ID
20472049
EC Number    EC: 2.7.1.95     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.95
Lineage    Species: Acinetobacter baumannii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Moraxellaceae
Genus: Acinetobacter
Species: Acinetobacter baumannii
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human lung.
Sequence
MELPNIIQQFIGNSVLEPNKIGQSPSDVYSFNRNNETFFLKRSSTLYTETTYSVSREAKM
LSWLSEKLKVPELIMTFQDEQFEFMITKAINAKPISALFLTDQELLAIYKEALNLLNSIA
IIDCPFISNIDHRLKESKFFIDNQLLDDIDQDDFDTELWGDHKTYLSLWNELTETRVEER
LVFSHGDITDSNIFIDKFNEIYFLDLGRAGLADEFVDISFVERCLREDASEETAKIFLKH
LKNDRPDKRNYFLKLDELN
Structure
1P40
Function This enzyme acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          7 Drugs
Amikacin
 Drug Info Approved Pseudomonas infection ICD11: 1G40 [1]
Gentamicin
 Drug Info Approved Acute upper respiratory infection ICD11: CA07 [1]
Kanamycin
 Drug Info Approved Pulmonary tuberculosis ICD11: 1B10 [1]
Neomycin
 Drug Info Approved Hepatic encephalopathy ICD11: DB99 [1]
Netilmicin
 Drug Info Approved Acute upper respiratory infection ICD11: CA07 [1]
Streptomycin
 Drug Info Approved Infectious endocarditis ICD11: BB40 [1]
Tobramycin
 Drug Info Approved Conjunctivitis ICD11: 9A60 [1]
References
1 Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5.

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