Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1068)
DME Name Aminoglycoside O-phosphotransferase (aphA6), Acinetobacter baumannii DME Info
UniProt ID
KKA6_ACIBA
EC Number    EC: 2.7.1.95     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.95
Lineage    Species: Acinetobacter baumannii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Moraxellaceae
Genus: Acinetobacter
Species: Acinetobacter baumannii
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      14 Xenobiotics
                              Caerulein precursor fragment-SP1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02942   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Caerulein precursor fragment-SP1 inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii [1]
                              Cathelicidin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02731   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cathelicidin inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii [2]
                              Coleoptericin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02900   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Coleoptericin inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii [3]
                              CP-P derivative K11 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03678   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CP-P derivative K11 inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii (MIC = 0.8 ug/ml) [4]
                              CP-P derivative S16 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04888   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CP-P derivative S16 inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii (MIC = 3.125 ug/ml) [4]
                              CTX-1 peptide NCP-3a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04241   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CTX-1 peptide NCP-3a inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii [5]
                              CTX-1 peptide NCP-3b Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04242   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CTX-1 peptide NCP-3b inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii [5]
                              Hagfish HFIAP-1/2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03556   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hagfish HFIAP-1/2 inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii (MIC = 8-16 ug/ml) [6]
                              Hagfish HFIAP-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03557   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hagfish HFIAP-3 inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii (MIC = 8-16 ug/ml) [6]
                              Hematopoietic antimicrobial MgCath37 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03540   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hematopoietic antimicrobial MgCath37 inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii (MIC = 8-16 ug/ml) [6]
                              Hydramacin Hm-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03609   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hydramacin Hm-1 inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii [7], [8]
                              Mastoparan MP-L Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04001   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mastoparan MP-L inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii (MIC = 2.7 microM) [9]
                              Mastoparan-L [I5,R8] derivative Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01816   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mastoparan-L [I5,R8] derivative inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii (MIC = 3 microM) [9]
                              TL(3)[Pro3,DLeu9] Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01824   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation TL(3)[Pro3,DLeu9] inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii (MIC = 50 microM) [10]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Linalool Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01366   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Linalool inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii [11]
      Pharmaceutical Agent(s)
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Norspermidine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04331   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Norspermidine inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii [12]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Polyethyleneimine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04686   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Polyethyleneimine inhibits the drug-metabolizing activity of Aminoglycoside O-phosphotransferase (aphA6) from Acinetobacter baumannii [13]
References
1 Genome duplications within the Xenopodinae do not increase the multiplicity of antimicrobial peptides in Silurana paratropicalis and Xenopus andrei skin secretions. Comp Biochem Physiol Part D Genomics Proteomics. 2011 Jun;6(2):206-12.
2 The human antimicrobial peptide LL-37 and its fragments possess both antimicrobial and antibiofilm activities against multidrug-resistant Acinetobacter baumannii. Peptides. 2013 Nov;49:131-7.
3 Insect immunityIsolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family. J Biol Chem. 1991 Dec 25;266(36):24520-5.
4 The Design and Construction of K11: A Novel alpha-Helical Antimicrobial Peptide. Int J Microbiol. 2012;2012:764834.
5 Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity. PLoS One. 2018 Jan 24;13(1):e0190778.
6 Hagfish intestinal antimicrobial peptides are ancient cathelicidins. Peptides. 2003 Nov;24(11):1655-67.
7 Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence. Dev Comp Immunol. 2009 Apr;33(4):559-69.
8 Hydramacin-1, structure and antibacterial activity of a protein from the basal metazoan Hydra. J Biol Chem. 2009 Jan 16;284(3):1896-905.
9 Selective amino acid substitution reduces cytotoxicity of the antimicrobial peptide mastoparan. Biochim Biophys Acta. 2016 Nov;1858(11):2699-2708.
10 Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: evaluation of antimicrobial, cytotoxic and hemolytic activities. Eur J Med Chem. 2017 Oct 20;139:750-761.
11 Study of the major essential oil compounds of Coriandrum sativum against Acinetobacter baumannii and the effect of linalool on adhesion, biofilms and quorum sensing. Biofouling. 2016;32(2):155-65.
12 Activity of norspermidine on bacterial biofilms of multidrug-resistant clinical isolates associated with persistent extremity wound infections. Adv Exp Med Biol. 2017;973:53-70.
13 Polyethyleneimine and polyethyleneimine-based nanoparticles: novel bacterial and yeast biofilm inhibitors. J Med Microbiol. 2014 Sep;63(Pt 9):1167-1173.

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