Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5505)
Drug Name
Aminolevulinic Acid Hydrochloride
Synonyms Levulan; Levulan Kerastick
Indication Actinic keratosis [ICD11: EK90] Approved [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 167.59 Topological Polar Surface Area 80.4
Heavy Atom Count 10 Rotatable Bond Count 4
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Cross-matching ID
PubChem CID
123608
ChEBI ID
CHEBI:132969
CAS Number
5451-09-2
TTD Drug ID
D0O4GY
Formula
C5H10ClNO3
Canonical SMILES
C(CC(=O)O)C(=O)CN.Cl
InChI
InChI=1S/C5H9NO3.ClH/c6-3-4(7)1-2-5(8)9;/h1-3,6H2,(H,8,9);1H
InChIKey
ZLHFONARZHCSET-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Porphobilinogen DM014840
1021
Unclear - Unclear 1 [2]
Coproporphyrinogen III DM019926 N. A. Unclear - Unclear 2 [2]
Protoporphyrinogen IX DM015136
121893
Unclear - Unclear 3 [2]
Protoporphyrin IX DM014877
4971
Unclear - Unclear 4 [2]
Heme DM014995
26945
Unclear - Unclear 5 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR012754 Aminolevulinic Acid Hydrochloride Porphobilinogen Unclear - Unclear ALAD [2]
MR012755 Porphobilinogen Coproporphyrinogen III Unclear - Unclear HMBS [2]
MR012756 Coproporphyrinogen III Protoporphyrinogen IX Unclear - Unclear CPOX [2]
MR012757 Protoporphyrinogen IX Protoporphyrin IX Unclear - Unclear PPOX [2]
MR012758 Protoporphyrin IX Heme Unclear - Unclear FECH [2]
References
1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Molecular and Metabolic Mechanisms Underlying Selective 5-Aminolevulinic Acid-Induced Fluorescence in Gliomas

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