Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000917)
Formula	CYP2D6
	Reactant	Erdafitinib	Product	Erdafitinib metabolite M11
	Reactant	Reactant Info	Product	Product Info
Metabolic Enzyme	Cytochrome P450 2D6 (CYP2D6)				DME Info

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR000921	Erdafitinib	Erdafitinib metabolite M28	Unclear	Erdafitinib	[1]
MR000918	Erdafitinib	Erdafitinib metabolite M5	Oxidation - O-Demethylation	Erdafitinib	[1]
MR000919	Erdafitinib	Erdafitinib metabolite M6	Oxidation - O-Demethylation	Erdafitinib	[1]
MR000920	Erdafitinib	Erdafitinib metabolite M8	Oxidation - N-Dealkylation	Erdafitinib	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR000916	Erdafitinib metabolite M11	Erdafitinib metabolite M27	Oxidation - O-Demethylation	Erdafitinib	[1]

References
1	Metabolism and disposition in rats, dogs, and humans of erdafitinib, an orally administered potent pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor Xenobiotica. 2021 Feb;51(2):177-193. doi: 10.1080/00498254.2020.1821123.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.