Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000918)
Formula Reactant Erdafitinib Product Erdafitinib metabolite M5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000917 Erdafitinib Erdafitinib metabolite M11 Unclear Erdafitinib [1]
MR000921 Erdafitinib Erdafitinib metabolite M28 Unclear Erdafitinib [1]
MR000919 Erdafitinib Erdafitinib metabolite M6 Oxidation - O-Demethylation Erdafitinib [1]
MR000920 Erdafitinib Erdafitinib metabolite M8 Oxidation - N-Dealkylation Erdafitinib [1]
References
1 Metabolism and disposition in rats, dogs, and humans of erdafitinib, an orally administered potent pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor Xenobiotica. 2021 Feb;51(2):177-193. doi: 10.1080/00498254.2020.1821123.

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