Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000920)
Formula Reactant Erdafitinib Product Erdafitinib metabolite M8
Reactant Info Product Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000917 Erdafitinib Erdafitinib metabolite M11 Unclear Erdafitinib [1]
MR000921 Erdafitinib Erdafitinib metabolite M28 Unclear Erdafitinib [1]
MR000918 Erdafitinib Erdafitinib metabolite M5 Oxidation - O-Demethylation Erdafitinib [1]
MR000919 Erdafitinib Erdafitinib metabolite M6 Oxidation - O-Demethylation Erdafitinib [1]
References
1 Metabolism and disposition in rats, dogs, and humans of erdafitinib, an orally administered potent pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor Xenobiotica. 2021 Feb;51(2):177-193. doi: 10.1080/00498254.2020.1821123.

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