Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000944)
Formula
SVG example
Oxidation
Reactant Eslicarbazepine Product Oxcarbazepine
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000946 Eslicarbazepine acetate Eslicarbazepine Unclear Eslicarbazepine acetate [1]
MR001871 Oxcarbazepine Eslicarbazepine Reduction - Reduction Oxcarbazepine [2]
MR000948 Oxcarbazepine Eslicarbazepine Reduction - Reduction Eslicarbazepine acetate [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000945 Eslicarbazepine Eslicarbazepine-O-glucuronide metabolite Unclear Eslicarbazepine acetate [1], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010355 Licarbazepine Oxcarbazepine Unclear - Unclear Licarbazepine [5]
References
1 Pharmacokinetics and drug interactions of eslicarbazepine acetate Epilepsia. 2012 Jun;53(6):935-46. doi: 10.1111/j.1528-1167.2012.03519.x.
2 The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man. Chem Biol Interact. 2014 Sep 5;220:241-7.
3 U. S. FDA Label -Eslicarbazepine acetate
4 Key factors in the discovery and development of new antiepileptic drugs Nat Rev Drug Discov. 2010 Jan;9(1):68-82. doi: 10.1038/nrd2997.
5 Pharmacokinetics of licarbazepine in healthy volunteers: single and multiple oral doses and effect of food

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