Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000945)
Formula Reactant Eslicarbazepine Product Eslicarbazepine-O-glucuronide metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000946 Eslicarbazepine acetate Eslicarbazepine Unclear Eslicarbazepine acetate [1]
MR001871 Oxcarbazepine Eslicarbazepine Reduction - Reduction Oxcarbazepine [2]
MR000948 Oxcarbazepine Eslicarbazepine Reduction - Reduction Eslicarbazepine acetate [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000944 Eslicarbazepine Oxcarbazepine Oxidation - Oxidation Eslicarbazepine acetate [1], [4]
References
1 Pharmacokinetics and drug interactions of eslicarbazepine acetate Epilepsia. 2012 Jun;53(6):935-46. doi: 10.1111/j.1528-1167.2012.03519.x.
2 The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man. Chem Biol Interact. 2014 Sep 5;220:241-7.
3 U. S. FDA Label -Eslicarbazepine acetate
4 Key factors in the discovery and development of new antiepileptic drugs Nat Rev Drug Discov. 2010 Jan;9(1):68-82. doi: 10.1038/nrd2997.

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