Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001168)
Formula
SVG example
Oxidation
Reactant Imrecoxib metabolite M4 Product Imrecoxib metabolite M2
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001174 Imrecoxib Imrecoxib metabolite M4 Oxidation - Oxidation Imrecoxib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001170 Imrecoxib metabolite M4 Imrecoxib metabolite M1 Oxidation - Oxidation Imrecoxib [2]
MR001169 Imrecoxib metabolite M4 Imrecoxib metabolite M3 Oxidation - Hydroxylation Imrecoxib [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001173 Imrecoxib metabolite M1 Imrecoxib metabolite M2 Unclear Imrecoxib [4], [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001171 Imrecoxib metabolite M2 Imrecoxib metabolite M6 Conjugation - Glucuronidation Imrecoxib [6]
References
1 Metabolism and excretion of imrecoxib in rat Xenobiotica. 2006 May;36(5):441-55. doi: 10.1080/00498250600595524.
2 Exposures to estradiol, ethinylestradiol and octylphenol affect survival and growth of Rana pipiens and Rana sylvatica tadpoles J Toxicol Environ Health A. 2006 Aug;69(16):1555-69. doi: 10.1080/15287390500470759.
3 Database composition can affect the structure-activity relationship prediction J Toxicol Environ Health A. 2006 Aug;69(16):1527-40. doi: 10.1080/15287390500468746.
4 Differences in the In Vivo and In Vitro Metabolism of Imrecoxib in Humans: Formation of the Rate-Limiting Aldehyde Intermediate Drug Metab Dispos. 2018 Sep;46(9):1320-1328. doi: 10.1124/dmd.118.081182.
5 Comparative Pharmacokinetics and Safety of Imrecoxib, a Novel Selective Cyclooxygenase-2 Inhibitor, in Elderly Healthy Subjects. Drug Des Devel Ther. 2022 Nov 8;16:3865-3876. doi: 10.2147/DDDT.S387508.
6 Ozone exposure impairs antigen-specific immunity but activates IL-7-induced proliferation of CD4-CD8- thymocytes in BALB/c mice J Toxicol Environ Health A. 2006 Aug;69(16):1511-26. doi: 10.1080/15287390500468696.

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