Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001355)
Formula Reactant Ketoconazole Product M8 (Ketoconazole)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001357 Ketoconazole Ketoconazole epoxide intermediate Unclear Ketoconazole [1]
MR001352 Ketoconazole M13 (Ketoconazole) Oxidation - N-Oxidation Ketoconazole [1]
MR001353 Ketoconazole M14 (Ketoconazole) Oxidation - Deacetylation Ketoconazole [1]
MR001354 Ketoconazole M7 (Ketoconazole) Oxidation - Oxidation Ketoconazole [1]
MR001356 Ketoconazole M9 (Ketoconazole) Oxidation - Hydoxylation Ketoconazole [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001339 M8 (Ketoconazole) M6 (Ketoconazole) Oxidation - Hydroxylation Ketoconazole [1]
References
1 Revisiting the metabolism of ketoconazole using accurate mass Drug Metab Lett. 2009 Aug;3(3):191-8. doi: 10.2174/187231209789352085.

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