Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001448)
Formula
SVG example
Oxidative Deamination
Reactant Levamlodipine metabolite M9 Product Levamlodipine metabolite M10
Reactant Info Product Info
Metabolic Type Oxidation - Oxidative Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001452 Levamlodipine Levamlodipine metabolite M9 Oxidation - Dehydrogenation Levamlodipine [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001449 Levamlodipine metabolite M9 Levamlodipine metabolite M1 Unclear Levamlodipine [1], [2]
MR001450 Levamlodipine metabolite M9 Levamlodipine metabolite M4 Oxidation - O-Dealkylation Levamlodipine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001451 Levamlodipine metabolite M10 Levamlodipine metabolite M12 Unclear Levamlodipine [1], [2]
References
1 Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation. Drug Metab Dispos. 2014 Feb;42(2):245-9.
2 Absence of excretion of the active moiety of bisacodyl and sodium picosulfate into human breast milk: an open-label, parallel-group, multiple-dose study in healthy lactating women Drug Metab Pharmacokinet. 2011;26(5):458-64. doi: 10.2133/dmpk.dmpk-11-rg-007.

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