Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001452)
Formula
SVG example
Dehydrogenation
Reactant Levamlodipine Product Levamlodipine metabolite M9
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Dehydrogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001453 Levamlodipine Levamlodipine metabolite M6 Unclear Levamlodipine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001449 Levamlodipine metabolite M9 Levamlodipine metabolite M1 Unclear Levamlodipine [1], [2]
MR001448 Levamlodipine metabolite M9 Levamlodipine metabolite M10 Oxidation - Oxidative Deamination Levamlodipine [1], [2]
MR001450 Levamlodipine metabolite M9 Levamlodipine metabolite M4 Oxidation - O-Dealkylation Levamlodipine [1], [2]
References
1 Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation. Drug Metab Dispos. 2014 Feb;42(2):245-9.
2 Absence of excretion of the active moiety of bisacodyl and sodium picosulfate into human breast milk: an open-label, parallel-group, multiple-dose study in healthy lactating women Drug Metab Pharmacokinet. 2011;26(5):458-64. doi: 10.2133/dmpk.dmpk-11-rg-007.

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