Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002034)
Formula
SVG example
Reactant Phenytoin dihydrodiol Product Phenytoin catechol
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002036 Phenytoin Phenytoin dihydrodiol Oxidation - Dihydroxylation; Oxidation Phenytoin [1]
MR003163 Phenytoin arene-oxide Phenytoin dihydrodiol Oxidation - Dihydroxylation Fosphenytoin sodium [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002030 Hydroxyphenytoin Phenytoin catechol Oxidation - Oxidation Phenytoin [3]
MR003164 Hydroxyphenytoin Phenytoin catechol Oxidation - Oxidation Fosphenytoin sodium [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002032 Phenytoin catechol Phenytoin methylcatechol Conjugation - Methylation Phenytoin [3]
MR002033 Phenytoin catechol Phenytoin quinone Oxidation - Oxidation Phenytoin [3]
MR003166 Phenytoin catechol Phenytoin methylcatechol Conjugation - Methylation Fosphenytoin sodium [2]
MR003167 Phenytoin catechol Phenytoin quinone Oxidation - Oxidation Fosphenytoin sodium [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 DrugBank(Pharmacology-Metabolism)Fosphenytoin sodium
3 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.

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