Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003163)
Formula
SVG example
Dihydroxylation
Reactant Phenytoin arene-oxide Product Phenytoin dihydrodiol
Reactant Info Product Info
Metabolic Type Oxidation - Dihydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002035 Phenytoin Phenytoin arene-oxide Oxidation - Oxidation Phenytoin [1]
MR003172 Phenytoin Phenytoin arene-oxide Oxidation - Oxidation Fosphenytoin sodium [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002029 Phenytoin arene-oxide Hydroxyphenytoin Unclear Phenytoin [1]
MR003162 Phenytoin arene-oxide Hydroxyphenytoin Unclear Fosphenytoin sodium [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002036 Phenytoin Phenytoin dihydrodiol Oxidation - Dihydroxylation; Oxidation Phenytoin [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002034 Phenytoin dihydrodiol Phenytoin catechol Unclear Phenytoin [2]
MR003169 Phenytoin dihydrodiol Phenytoin catechol Unclear Fosphenytoin sodium [3]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 DrugBank(Pharmacology-Metabolism)Fosphenytoin sodium

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