Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002036)
Formula
CYP3A4 ...
SVG example
Dihydroxylation; Oxidation
Reactant Phenytoin Product Phenytoin dihydrodiol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Epoxide hydrolase 1 (EPHX1) DME Info
Metabolic Type Oxidation - Dihydroxylation; Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002035 Phenytoin Phenytoin arene-oxide Oxidation - Oxidation Phenytoin [1]
MR003172 Phenytoin Phenytoin arene-oxide Oxidation - Oxidation Fosphenytoin sodium [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003163 Phenytoin arene-oxide Phenytoin dihydrodiol Oxidation - Dihydroxylation Fosphenytoin sodium [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002034 Phenytoin dihydrodiol Phenytoin catechol Unclear Phenytoin [3]
MR003169 Phenytoin dihydrodiol Phenytoin catechol Unclear Fosphenytoin sodium [2]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 DrugBank(Pharmacology-Metabolism)Fosphenytoin sodium
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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