Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002363)
Formula
SVG example
Reactant Telaprevir Product Pyrazinoic acid
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002364 Telaprevir . Reduction - Reduction Telaprevir [1]
MR002362 Telaprevir R-diastereomer of telaprevir Unclear Telaprevir [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002201 Pyrazinamide Pyrazinoic acid Oxidation - Oxidation Pyrazinamide [2], [3], [4]
MR009315 Pyrazinoylguanidine PZA Unclear - Unclear Pyrazinoylguanidine [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009317 PZA 2-Pyrazinuric acid Oxidation - C11-hydroxylation Pyrazinoylguanidine [6]
MR002199 Pyrazinoic acid 5-hydroxypyrazinoic acid Unclear Pyrazinamide [2], [3], [4]
MR009316 PZA OHPZA Unclear - Unclear Pyrazinoylguanidine [5]
References
1 NCIVEK- telaprevir tablet, film coated Vertex Pharmaceuticals Incorporated
2 Factors Affecting the Pharmacokinetics of Pyrazinamide and Its Metabolites in Patients Coinfected with HIV and Implications for Individualized Dosing Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0004621. doi: 10.1128/AAC.00046-21.
3 Metabolism and Hepatotoxicity of Pyrazinamide, an Antituberculosis Drug Drug Metab Dispos. 2021 Aug;49(8):679-682. doi: 10.1124/dmd.121.000389.
4 Determination of pyrazinamide and its main metabolites in rat urine by high-performance liquid chromatography J Chromatogr B Biomed Sci Appl. 1997 Aug 1;695(2):365-72. doi: 10.1016/s0378-4347(97)00175-8.
5 Pharmacokinetics of pyrazinoyl-guanidine, 3-aminopyrazinoyl-guanidine and their corresponding pyrazinoic acid metabolites in humans and dogs
6 A bradykinin antagonist inhibits carrageenan edema in rats

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