Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002429)
Formula Reactant Trabectedin Product Trabectedin metabolite M11a
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002433 Trabectedin Trabectedin metabolite M16c Oxidation - O-Demethylation Trabectedin [1]
MR002431 Trabectedin Trabectedin metabolite M16e Oxidation - Oxidation; Carboxylic Acid Formation Trabectedin [1]
MR002428 Trabectedin Trabectedin metabolite M4b Oxidation - Demethylation; Oxidation Trabectedin [1]
MR002430 Trabectedin Trabectedin metabolite M8a Unclear Trabectedin [1]
MR002432 Trabectedin Trabectedin metabolite M8b Oxidation - N-Demethylation Trabectedin [1]
MR002434 Trabectedin Trabectedin metabolite M9 Unclear Trabectedin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002426 Trabectedin metabolite M11a Trabectedin metabolite M16b Oxidation - Oxidation Trabectedin [1]
References
1 In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping Biochem Pharmacol. 2009 May 15;77(10):1642-54. doi: 10.1016/j.bcp.2009.02.020.

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