Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002431)
Formula
SVG example
Oxidation; Carboxylic Acid Formation
Reactant Trabectedin Product Trabectedin metabolite M16e
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation; Carboxylic Acid Formation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002429 Trabectedin Trabectedin metabolite M11a Oxidation - Oxidation Trabectedin [1]
MR002433 Trabectedin Trabectedin metabolite M16c Oxidation - O-Demethylation Trabectedin [1]
MR002428 Trabectedin Trabectedin metabolite M4b Oxidation - Demethylation; Oxidation Trabectedin [1]
MR002430 Trabectedin Trabectedin metabolite M8a Unclear Trabectedin [1]
MR002432 Trabectedin Trabectedin metabolite M8b Oxidation - N-Demethylation Trabectedin [1]
MR002434 Trabectedin Trabectedin metabolite M9 Unclear Trabectedin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002427 Trabectedin metabolite M8a Trabectedin metabolite M16e Oxidation - Oxidation Trabectedin [1]
References
1 In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping Biochem Pharmacol. 2009 May 15;77(10):1642-54. doi: 10.1016/j.bcp.2009.02.020.

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