Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002428)
Formula Reactant Trabectedin Product Trabectedin metabolite M4b
Reactant Info Product Info
Metabolic Type Oxidation - Demethylation; Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002429 Trabectedin Trabectedin metabolite M11a Oxidation - Oxidation Trabectedin [1]
MR002433 Trabectedin Trabectedin metabolite M16c Oxidation - O-Demethylation Trabectedin [1]
MR002431 Trabectedin Trabectedin metabolite M16e Oxidation - Oxidation; Carboxylic Acid Formation Trabectedin [1]
MR002430 Trabectedin Trabectedin metabolite M8a Unclear Trabectedin [1]
MR002432 Trabectedin Trabectedin metabolite M8b Oxidation - N-Demethylation Trabectedin [1]
MR002434 Trabectedin Trabectedin metabolite M9 Unclear Trabectedin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002424 Trabectedin metabolite M4b Trabectedin metabolite M16d Oxidation - Oxidation Trabectedin [1]
MR002423 Trabectedin metabolite M4b Trabectedin metabolite M4a Oxidation - Oxidation Trabectedin [1]
References
1 In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping Biochem Pharmacol. 2009 May 15;77(10):1642-54. doi: 10.1016/j.bcp.2009.02.020.

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