Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003162)
Formula
SVG example
Reactant Phenytoin arene-oxide Product Hydroxyphenytoin
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002035 Phenytoin Phenytoin arene-oxide Oxidation - Oxidation Phenytoin [1]
MR003172 Phenytoin Phenytoin arene-oxide Oxidation - Oxidation Fosphenytoin sodium [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003163 Phenytoin arene-oxide Phenytoin dihydrodiol Oxidation - Dihydroxylation Fosphenytoin sodium [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002031 Hydroxyphenytoin 4-hydroxyphenytoin o-glucuronide Conjugation - O-Glucuronidation Phenytoin [1], [3]
MR002030 Hydroxyphenytoin Phenytoin catechol Oxidation - Oxidation Phenytoin [1]
MR003165 Hydroxyphenytoin Hydroxyphenytoin-O-glucuronide metabolite Unclear Fosphenytoin sodium [4]
MR003164 Hydroxyphenytoin Phenytoin catechol Oxidation - Oxidation Fosphenytoin sodium [1]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 DrugBank(Pharmacology-Metabolism)Fosphenytoin sodium
3 Biotransformation of phenytoin in the electrochemically-driven CYP2C19 system. Biophys Chem. 2022 Dec;291:106894. doi: 10.1016/j.bpc.2022.106894.
4 U. S. FDA Label -Fosphenytoin sodium

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