Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003254)
Formula
UGT1A8 ...
SVG example
Glucuronidation
Reactant 4-Quinol sulfate Product 4-hydroxymethylpyrazole
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002183 4-hydroxypropofol 4-Quinol sulfate Other reaction - Sulfonation Propofol [1]
MR003253 4-hydroxypropofol 4-Quinol sulfate Other reaction - Sulfonation Fospropofol [1]
MR007836 4-Hydroxypropofol 4-Hydroxypropofol-O-sulphate Unclear - Unclear Fospropofol disodium [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007837 4-Hydroxypropofol-O-sulphate 2-(omega-Propanol)-4-hydroxypropofol-O-sulfate Unclear - Unclear Fospropofol disodium [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001086 Fomepizole 4-hydroxymethylpyrazole Unclear Fomepizole [3]
MR005975 GTPL-463 4-hydroxymethylpyrazole Unclear GTPL-463 [4]
MR003260 Propofol 4-hydroxymethylpyrazole Unclear Fospropofol [5]
MR003255 Propofol glucuronide 4-hydroxymethylpyrazole Oxidation - 4-Hydroxylation Fospropofol [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects
3 DrugBank(Pharmacology-Metabolism)Fomepizole
4 DrugBank(Pharmacology-Metabolism):GTPL-463 Fomepizole
5 DrugBank(Pharmacology-Metabolism)Fospropofol

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.