Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005975)
Formula
SVG example
Reactant GTPL-463 Product 4-hydroxymethylpyrazole
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005974 GTPL-463 4-carboxypyrazole Unclear GTPL-463 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001086 Fomepizole 4-hydroxymethylpyrazole Unclear Fomepizole [2]
MR003260 Propofol 4-hydroxymethylpyrazole Unclear Fospropofol [3]
MR003255 Propofol glucuronide 4-hydroxymethylpyrazole Oxidation - 4-Hydroxylation Fospropofol [4]
MR003254 4-Quinol sulfate 4-hydroxymethylpyrazole Conjugation - Glucuronidation Fospropofol [4]
References
1 Treatment of patients with ethylene glycol or methanol poisoning: focus on fomepizole. Open Access Emerg Med. 2010 Aug 24;2:67-75.
2 DrugBank(Pharmacology-Metabolism)Fomepizole
3 DrugBank(Pharmacology-Metabolism)Fospropofol
4 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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