Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003304)
Formula
UGT
SVG example
Reactant Valdecoxib Product Valdecoxib N-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003302 Valdecoxib Valdecoxib metabolite M1 Oxidation - Methyl-Hydroxylation Valdecoxib [1], [2]
MR003301 Valdecoxib Valdecoxib metabolite M2 Oxidation - N-Oxidation Valdecoxib [1], [2]
MR003303 Valdecoxib Valdecoxib metabolite M9 Oxidation - Hydroxylation Valdecoxib [1]
MR003485 Valdecoxib Valdecoxib metabolite M1 Oxidation - Methyl-Hydroxylation Parecoxib [1], [2]
MR003480 Valdecoxib Valdecoxib metabolite M2 Oxidation - N-Oxidation Parecoxib [2]
MR003491 Valdecoxib Valdecoxib metabolite M9 Oxidation - Hydroxylation Parecoxib [1], [2]
References
1 Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human Drug Metab Dispos. 2002 Sep;30(9):1013-21. doi: 10.1124/dmd.30.9.1013.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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