Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003302)
Formula
CYP2C9 ...
SVG example
Methyl-Hydroxylation
Reactant Valdecoxib Product Valdecoxib metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Methyl-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003301 Valdecoxib Valdecoxib metabolite M2 Oxidation - N-Oxidation Valdecoxib [1], [2]
MR003303 Valdecoxib Valdecoxib metabolite M9 Oxidation - Hydroxylation Valdecoxib [1]
MR003304 Valdecoxib Valdecoxib N-glucuronide Unclear Valdecoxib [1], [2]
MR003480 Valdecoxib Valdecoxib metabolite M2 Oxidation - N-Oxidation Parecoxib [2]
MR003491 Valdecoxib Valdecoxib metabolite M9 Oxidation - Hydroxylation Parecoxib [1], [2]
MR003496 Valdecoxib Valdecoxib N-glucuronide Conjugation - Glucuronidation Parecoxib [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003296 Valdecoxib metabolite M1 Valdecoxib metabolite M1-G Unclear Valdecoxib [2]
MR003294 Valdecoxib metabolite M1 Valdecoxib metabolite M3 Oxidation - Hydroxylation Valdecoxib [1]
MR003295 Valdecoxib metabolite M1 Valdecoxib metabolite M4 Oxidation - Oxidation Valdecoxib [2]
MR003293 Valdecoxib metabolite M1 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Valdecoxib [2]
MR003495 Valdecoxib metabolite M1 Valdecoxib metabolite M1-G Conjugation - Glucuronidation Parecoxib [2]
MR003487 Valdecoxib metabolite M1 Valdecoxib metabolite M3 Oxidation - Hydroxylation Parecoxib [1]
MR003489 Valdecoxib metabolite M1 Valdecoxib metabolite M4 Oxidation - Oxidation Parecoxib [2], [1]
MR003486 Valdecoxib metabolite M1 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Parecoxib [2]
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References
1 Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human Drug Metab Dispos. 2002 Sep;30(9):1013-21. doi: 10.1124/dmd.30.9.1013.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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