Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003301)
Formula
SVG example
N-Oxidation
Reactant Valdecoxib Product Valdecoxib metabolite M2
Reactant Info Product Info
Metabolic Type Oxidation - N-Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003302 Valdecoxib Valdecoxib metabolite M1 Oxidation - Methyl-Hydroxylation Valdecoxib [1], [2]
MR003303 Valdecoxib Valdecoxib metabolite M9 Oxidation - Hydroxylation Valdecoxib [1]
MR003304 Valdecoxib Valdecoxib N-glucuronide Unclear Valdecoxib [1], [2]
MR003485 Valdecoxib Valdecoxib metabolite M1 Oxidation - Methyl-Hydroxylation Parecoxib [1], [2]
MR003491 Valdecoxib Valdecoxib metabolite M9 Oxidation - Hydroxylation Parecoxib [1], [2]
MR003496 Valdecoxib Valdecoxib N-glucuronide Conjugation - Glucuronidation Parecoxib [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003290 Valdecoxib metabolite M2 Valdecoxib metabolite M2-G Unclear Valdecoxib [2]
MR003288 Valdecoxib metabolite M2 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Valdecoxib [2]
MR003289 Valdecoxib metabolite M2 Valdecoxib metabolite M7 Unclear Valdecoxib [1]
MR003494 Valdecoxib metabolite M2 Valdecoxib metabolite M2-G Conjugation - Glucuronidation Parecoxib [1], [2]
MR003481 Valdecoxib metabolite M2 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Parecoxib [2]
MR003483 Valdecoxib metabolite M2 Valdecoxib metabolite M7 Unclear Parecoxib [1]
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References
1 Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human Drug Metab Dispos. 2002 Sep;30(9):1013-21. doi: 10.1124/dmd.30.9.1013.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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