Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003486)
Formula
SVG example
Methyl-Hydroxylation
Reactant Valdecoxib metabolite M1 Product Valdecoxib metabolite M5
Reactant Info Product Info
Metabolic Type Oxidation - Methyl-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003302 Valdecoxib Valdecoxib metabolite M1 Oxidation - Methyl-Hydroxylation Valdecoxib [1], [2]
MR003485 Valdecoxib Valdecoxib metabolite M1 Oxidation - Methyl-Hydroxylation Parecoxib [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003296 Valdecoxib metabolite M1 Valdecoxib metabolite M1-G Unclear Valdecoxib [2]
MR003294 Valdecoxib metabolite M1 Valdecoxib metabolite M3 Oxidation - Hydroxylation Valdecoxib [1]
MR003295 Valdecoxib metabolite M1 Valdecoxib metabolite M4 Oxidation - Oxidation Valdecoxib [2]
MR003495 Valdecoxib metabolite M1 Valdecoxib metabolite M1-G Conjugation - Glucuronidation Parecoxib [2]
MR003487 Valdecoxib metabolite M1 Valdecoxib metabolite M3 Oxidation - Hydroxylation Parecoxib [1]
MR003489 Valdecoxib metabolite M1 Valdecoxib metabolite M4 Oxidation - Oxidation Parecoxib [2], [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003288 Valdecoxib metabolite M2 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Valdecoxib [2]
MR003481 Valdecoxib metabolite M2 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Parecoxib [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003291 Valdecoxib metabolite M5 Valdecoxib metabolite M5-G Conjugation - Glucuronidation Valdecoxib [2]
MR003482 Valdecoxib metabolite M5 Valdecoxib metabolite M5-G Conjugation - Glucuronidation Parecoxib [2]
References
1 Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human Drug Metab Dispos. 2002 Sep;30(9):1013-21. doi: 10.1124/dmd.30.9.1013.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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