Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003481)
Formula
SVG example
Methyl-Hydroxylation
Reactant Valdecoxib metabolite M2 Product Valdecoxib metabolite M5
Reactant Info Product Info
Metabolic Type Oxidation - Methyl-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003301 Valdecoxib Valdecoxib metabolite M2 Oxidation - N-Oxidation Valdecoxib [1], [2]
MR003480 Valdecoxib Valdecoxib metabolite M2 Oxidation - N-Oxidation Parecoxib [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003290 Valdecoxib metabolite M2 Valdecoxib metabolite M2-G Unclear Valdecoxib [2]
MR003289 Valdecoxib metabolite M2 Valdecoxib metabolite M7 Unclear Valdecoxib [1]
MR003494 Valdecoxib metabolite M2 Valdecoxib metabolite M2-G Conjugation - Glucuronidation Parecoxib [1], [2]
MR003483 Valdecoxib metabolite M2 Valdecoxib metabolite M7 Unclear Parecoxib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003293 Valdecoxib metabolite M1 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Valdecoxib [2]
MR003486 Valdecoxib metabolite M1 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Parecoxib [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003291 Valdecoxib metabolite M5 Valdecoxib metabolite M5-G Conjugation - Glucuronidation Valdecoxib [2]
MR003482 Valdecoxib metabolite M5 Valdecoxib metabolite M5-G Conjugation - Glucuronidation Parecoxib [2]
References
1 Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human Drug Metab Dispos. 2002 Sep;30(9):1013-21. doi: 10.1124/dmd.30.9.1013.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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