Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003494)
Formula
UGT
SVG example
Glucuronidation
Reactant Valdecoxib metabolite M2 Product Valdecoxib metabolite M2-G
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003301 Valdecoxib Valdecoxib metabolite M2 Oxidation - N-Oxidation Valdecoxib [1], [2]
MR003480 Valdecoxib Valdecoxib metabolite M2 Oxidation - N-Oxidation Parecoxib [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003288 Valdecoxib metabolite M2 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Valdecoxib [2]
MR003289 Valdecoxib metabolite M2 Valdecoxib metabolite M7 Unclear Valdecoxib [1]
MR003481 Valdecoxib metabolite M2 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Parecoxib [2]
MR003483 Valdecoxib metabolite M2 Valdecoxib metabolite M7 Unclear Parecoxib [1]
References
1 Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human Drug Metab Dispos. 2002 Sep;30(9):1013-21. doi: 10.1124/dmd.30.9.1013.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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