Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003527)
Formula Reactant 4-hydroxytamoxifen Product Tamoxifen glucuronides
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003526 Tamoxifen citrate 4-hydroxytamoxifen Oxidation - 4-Hydroxylation Tamoxifen citrate [1], [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003528 4-hydroxytamoxifen 4-hydroxytamoxifen sulfate Conjugation - Sulfation Tamoxifen citrate [5]
MR003530 4-hydroxytamoxifen Endoxifen Conjugation - Sulfation Tamoxifen citrate [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003520 Endoxifen Tamoxifen glucuronides Conjugation - Glucuronidation Tamoxifen citrate [5]
References
1 Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74.
2 Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50.
3 Metabolism and transport of tamoxifen in relation to its effectiveness: new perspectives on an ongoing controversy. Future Oncol. 2014 Jan;10(1):107-22.
4 The tamoxifen dilemma. Carcinogenesis. 1999 Jul;20(7):1153-60.
5 PharmGKB:Tamoxifen citrate

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