Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003520)
Formula Reactant Endoxifen Product Tamoxifen glucuronides
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011558 Endoxifen Endoxifen O-Glucuronide Unclear - Unclear Endoxifen [1]
MR011559 Endoxifen Endoxifen Sulfate Unclear - Unclear Endoxifen [1]
MR011557 Endoxifen Norendoxifen Oxidation - Demethylation Endoxifen [1]
MR003519 Endoxifen 4-endoxifen sulfate Conjugation - Sulfation Tamoxifen citrate [2]
MR003518 Endoxifen 4-hydroxytamoxifen sulfate Conjugation - Sulfation Tamoxifen citrate [2]
MR003517 Endoxifen Norendoxifen Oxidation - Demethylation Tamoxifen citrate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003527 4-hydroxytamoxifen Tamoxifen glucuronides Conjugation - Glucuronidation Tamoxifen citrate [2]
References
1 Clinical pharmacokinetics and pharmacogenetics of tamoxifen and endoxifen
2 PharmGKB:Tamoxifen citrate

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