Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003960)
Formula
SVG example
Cyclization; Glutamyl removal; glutathione conjugation
Reactant MK-0822 Product MK-0822 Metabolite M6 (Odanacatib)
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - Cyclization; Glutamyl removal; glutathione conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003963 MK-0822 MK-0822 Metabolite M1-A Unclear MK-0822 [1]
MR003962 MK-0822 MK-0822 Metabolite M10 (Odanacatib) Multi-steps Reaction - Glucuronidation; hydrolysis MK-0822 [2]
MR003958 MK-0822 MK-0822 Metabolite M4 Unclear MK-0822 [1]
MR003953 MK-0822 MK-0822 Metabolite M8 (Odanacatib) Oxidation - Hydrolyzationn MK-0822 [2]
MR003961 MK-0822 MK-0822 Metabolite M9 (Odanacatib) Multi-steps Reaction - N-dealkylation; glucuronidation MK-0822 [2]
References
1 Pharmacokinetics and metabolism in rats, dogs, and monkeys of the cathepsin k inhibitor odanacatib: demethylation of a methylsulfonyl moiety as a major metabolic pathway
2 Disposition and metabolism of the cathepsin K inhibitor odanacatib in humans. Drug Metab Dispos. 2014 May;42(5):818-27.

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