Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003961)
Formula
SVG example
N-dealkylation; glucuronidation
Reactant MK-0822 Product MK-0822 Metabolite M9 (Odanacatib)
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - N-dealkylation; glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003963 MK-0822 MK-0822 Metabolite M1-A Unclear MK-0822 [1]
MR003962 MK-0822 MK-0822 Metabolite M10 (Odanacatib) Multi-steps Reaction - Glucuronidation; hydrolysis MK-0822 [2]
MR003958 MK-0822 MK-0822 Metabolite M4 Unclear MK-0822 [1]
MR003960 MK-0822 MK-0822 Metabolite M6 (Odanacatib) Multi-steps Reaction - Cyclization; Glutamyl removal; glutathione conjugation MK-0822 [2]
MR003953 MK-0822 MK-0822 Metabolite M8 (Odanacatib) Oxidation - Hydrolyzationn MK-0822 [2]
References
1 Pharmacokinetics and metabolism in rats, dogs, and monkeys of the cathepsin k inhibitor odanacatib: demethylation of a methylsulfonyl moiety as a major metabolic pathway
2 Disposition and metabolism of the cathepsin K inhibitor odanacatib in humans. Drug Metab Dispos. 2014 May;42(5):818-27.

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