Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003963)
Formula Reactant MK-0822 Product MK-0822 Metabolite M1-A
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003962 MK-0822 MK-0822 Metabolite M10 (Odanacatib) Multi-steps Reaction - Glucuronidation; hydrolysis MK-0822 [1]
MR003958 MK-0822 MK-0822 Metabolite M4 Unclear MK-0822 [2]
MR003960 MK-0822 MK-0822 Metabolite M6 (Odanacatib) Multi-steps Reaction - Cyclization; Glutamyl removal; glutathione conjugation MK-0822 [1]
MR003953 MK-0822 MK-0822 Metabolite M8 (Odanacatib) Oxidation - Hydrolyzationn MK-0822 [1]
MR003961 MK-0822 MK-0822 Metabolite M9 (Odanacatib) Multi-steps Reaction - N-dealkylation; glucuronidation MK-0822 [1]
References
1 Disposition and metabolism of the cathepsin K inhibitor odanacatib in humans. Drug Metab Dispos. 2014 May;42(5):818-27.
2 Pharmacokinetics and metabolism in rats, dogs, and monkeys of the cathepsin k inhibitor odanacatib: demethylation of a methylsulfonyl moiety as a major metabolic pathway

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