Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004867)
Formula
SVG example
Demethylation; Reduction
Reactant 5-methoxysalicylic acid Product Catechol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 monooxygenase 51A (cyp51A) DME Info
Metabolic Type Multi-steps Reaction - Demethylation; Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004866 5-methoxysalicylaldehyde 5-methoxysalicylic acid Unclear Naproxen [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004869 5-methoxysalicylic acid Gentistic acid Multi-steps Reaction - Demethylation; Reduction Naproxen [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012344 HPPH Catechol Unclear - Unclear HPPH [2]
MR004300 Benzoic acid Catechol Unclear Naphthoquinone [3]
MR010926 Guaiacol Catechol Unclear - Unclear Isovanillin [4]
MR010925 Protocatechuic acid Catechol Unclear - Unclear Isovanillin [4]
MR013587 Pyrogallol Catechol Unclear Epigallocatechin gallate [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004868 Catechol Cis-cis muconic acid Unclear Naproxen [1]
References
1 Utilization of naproxen by Amycolatopsis sp. Poz 14 and detection of the enzymes involved in the degradation metabolic pathway
2 Role of CYP2C9, CYP2C19 and EPHX Polymorphism in the Pharmacokinetic of Phenytoin: A Study on Uruguayan Caucasian Subjects
3 Identification of naphthalene metabolism by white rot fungus Pleurotus eryngii
4 The metabolism of vanillin and isovanillin in the rat
5 Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.