Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005115)
Formula	6-ketoreduction
	Reactant	Hydrocodone bitartrate	Product	6-beta-hydrocodol
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Reduction - 6-ketoreduction

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005114	Hydrocodone bitartrate	6-alpha-hydrocodol	Reduction - 6-ketoreduction	Hydrocodone bitartrate	[1], [2]
MR005109	Hydrocodone bitartrate	Hydromorphone	Oxidation - O-demethylation	Hydrocodone bitartrate	[2]
MR005123	Hydrocodone bitartrate	Norhydrocodone	Oxidation - N-demethylation	Hydrocodone bitartrate	[2]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005121	6-beta-hydrocodol	6-beta-hydrocodol glucuronide conjugate	Conjugation - O-glucuronidation	Hydrocodone bitartrate	[3]
MR005116	6-beta-hydrocodol	6-beta-hydromorphol	Oxidation - O-demethylation	Hydrocodone bitartrate	[3]

References
1	Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog
2	CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. Br J Clin Pharmacol. 2004 Mar;57(3):287-97.
3	DrugBank(Pharmacology-Metabolism):Hydrocodone bitartrate

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