Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005123)
Formula
SVG example
N-demethylation
Reactant Hydrocodone bitartrate Product Norhydrocodone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005114 Hydrocodone bitartrate 6-alpha-hydrocodol Reduction - 6-ketoreduction Hydrocodone bitartrate [1], [2]
MR005109 Hydrocodone bitartrate Hydromorphone Oxidation - O-demethylation Hydrocodone bitartrate [2]
MR005115 Hydrocodone bitartrate 6-beta-hydrocodol Reduction - 6-ketoreduction Hydrocodone bitartrate [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011205 Hydrocodone Norhydrocodone Oxidation - N-demethylation Hydrocodone [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011206 Norhydrocodone Hydrocodone M272 Multi-steps Reaction - N-demethylation; O-demethylation Hydrocodone [4]
MR011217 Norhydrocodone Norhydrocodol Reduction - Ketone reduction Hydrocodone [4]
References
1 Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog
2 CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. Br J Clin Pharmacol. 2004 Mar;57(3):287-97.
3 DrugBank(Pharmacology-Metabolism):Hydrocodone bitartrate
4 Update on hydrocodone metabolites in rats and dogs aided with a semi-automatic software for metabolite identification Mass-MetaSite

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.