Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005621)
Formula Reactant Selumetinib M8 (N-desmethyl selumetinib) Product Selumetinib M5 (glucuronidated N-desmethyl selumetinib)
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005610 Selumetinib Selumetinib M8 (N-desmethyl selumetinib) Oxidation - N-demethylation Selumetinib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005623 Selumetinib M8 (N-desmethyl selumetinib) Selumetinib M11 (N-demethylated carboxylic acid selumetinib metabolite) Oxidation - Oxidationn Selumetinib [1]
MR005611 Selumetinib M8 (N-desmethyl selumetinib) Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Other reaction - Elimination Selumetinib [1]
MR005622 Selumetinib M8 (N-desmethyl selumetinib) Selumetinib M3 (glucuronidated N-desmethyl selumetinib) Conjugation - Glucuronidation Selumetinib [1]
References
1 Metabolism, Excretion, and Pharmacokinetics of Selumetinib, an MEK1/2 inhibitor, in Healthy Adult Male Subjects

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