Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005611)
Formula Reactant Selumetinib M8 (N-desmethyl selumetinib) Product Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite)
Reactant Info Product Info
Metabolic Type Other reaction - Elimination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005610 Selumetinib Selumetinib M8 (N-desmethyl selumetinib) Oxidation - N-demethylation Selumetinib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005623 Selumetinib M8 (N-desmethyl selumetinib) Selumetinib M11 (N-demethylated carboxylic acid selumetinib metabolite) Oxidation - Oxidationn Selumetinib [1]
MR005622 Selumetinib M8 (N-desmethyl selumetinib) Selumetinib M3 (glucuronidated N-desmethyl selumetinib) Conjugation - Glucuronidation Selumetinib [1]
MR005621 Selumetinib M8 (N-desmethyl selumetinib) Selumetinib M5 (glucuronidated N-desmethyl selumetinib) Conjugation - Glucuronidation Selumetinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005615 Selumetinib M14 (AZ12791138) Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Other reaction - Elimination Selumetinib [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005612 Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Selumetinib M10 selumetinib metabolite Oxidation - Oxidationn Selumetinib [1]
MR005619 Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Selumetinib M13 (Primary amide, N-demethylated, mono-oxidized selumetinib metabolite) Oxidation - Oxidationn Selumetinib [1]
MR005620 Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Selumetinib M9 (ribose conjugated selumetinib metabolite) Conjugation - Ribose conjugation Selumetinib [1]
References
1 Metabolism, Excretion, and Pharmacokinetics of Selumetinib, an MEK1/2 inhibitor, in Healthy Adult Male Subjects

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