Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005625)
Formula	Amide hydrolysis
	Reactant	Selumetinib	Product	Selumetinib M15 (AZ13326637)
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Hydrolysis - Amide hydrolysis

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005614	Selumetinib	Selumetinib M14 (AZ12791138)	Unclear	Selumetinib	[1]
MR005626	Selumetinib	Selumetinib M4 (glucuronidated selumetinib)	Conjugation - Glucuronidation	Selumetinib	[1]
MR005627	Selumetinib	Selumetinib M7 (glucuronidated selumetinib)	Conjugation - Glucuronidation	Selumetinib	[1]
MR005610	Selumetinib	Selumetinib M8 (N-desmethyl selumetinib)	Oxidation - N-demethylation	Selumetinib	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005624	Selumetinib M14 (AZ12791138)	Selumetinib M15 (AZ13326637)	Hydrolysis - Amide hydrolysis	Selumetinib	[1]

References
1	Metabolism, Excretion, and Pharmacokinetics of Selumetinib, an MEK1/2 inhibitor, in Healthy Adult Male Subjects

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