Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005624)
Formula	Amide hydrolysis
	Reactant	Selumetinib M14 (AZ12791138)	Product	Selumetinib M15 (AZ13326637)
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Hydrolysis - Amide hydrolysis

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005614	Selumetinib	Selumetinib M14 (AZ12791138)	Unclear	Selumetinib	[1]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005615	Selumetinib M14 (AZ12791138)	Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite)	Other reaction - Elimination	Selumetinib	[1]
MR005616	Selumetinib M14 (AZ12791138)	Selumetinib M2 (amide glucuronide selumetinib metabolite)	Conjugation - Glucuronidation	Selumetinib	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR005625	Selumetinib	Selumetinib M15 (AZ13326637)	Hydrolysis - Amide hydrolysis	Selumetinib	[1]

References
1	Metabolism, Excretion, and Pharmacokinetics of Selumetinib, an MEK1/2 inhibitor, in Healthy Adult Male Subjects

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