Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005614)
Formula
SVG example
Reactant Selumetinib Product Selumetinib M14 (AZ12791138)
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005625 Selumetinib Selumetinib M15 (AZ13326637) Hydrolysis - Amide hydrolysis Selumetinib [1]
MR005626 Selumetinib Selumetinib M4 (glucuronidated selumetinib) Conjugation - Glucuronidation Selumetinib [1]
MR005627 Selumetinib Selumetinib M7 (glucuronidated selumetinib) Conjugation - Glucuronidation Selumetinib [1]
MR005610 Selumetinib Selumetinib M8 (N-desmethyl selumetinib) Oxidation - N-demethylation Selumetinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005615 Selumetinib M14 (AZ12791138) Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Other reaction - Elimination Selumetinib [1]
MR005624 Selumetinib M14 (AZ12791138) Selumetinib M15 (AZ13326637) Hydrolysis - Amide hydrolysis Selumetinib [1]
MR005616 Selumetinib M14 (AZ12791138) Selumetinib M2 (amide glucuronide selumetinib metabolite) Conjugation - Glucuronidation Selumetinib [1]
References
1 Metabolism, Excretion, and Pharmacokinetics of Selumetinib, an MEK1/2 inhibitor, in Healthy Adult Male Subjects

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